Article
HIV-1 protease codon 36 polymorphisms and differential development of resistance to nelfinavir, lopinavir, and atazanavir in different HIV-1 subtypes.
Antimicrobial agents and chemotherapy - 1 Jul 2010
Lisovsky Irene, Schader Susan M, Martinez-Cajas Jorge-Luis, Oliveira Maureen, Moisi Daniela, Wainberg Mark A
Abstract excerpt
The amino acid at position 36 of the HIV-1 protease differs among various viral subtypes, in that methionine is usually found in subtype B viruses but isoleucine is common in other subtypes. This polymorphism is associated with higher rates of treatment failure involving protease inhibitors (PIs) in non-subtype B-infected patients. To investigate this, we generated genetically homogeneous wild-type viruses from...
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