Article
Variant human immunodeficiency virus type 1 proteases and response to combination therapy including a protease inhibitor.
Antimicrobial agents and chemotherapy - 1 Mar 2001
Servais J, Lambert C, Fontaine E, Plesséria J M, Robert I, Arendt V, Staub T, Schneider F, Hemmer R, Burtonboy G, Schmit J C
Abstract excerpt
The objective of this observational study was to assess the genetic variability in the human immunodeficiency virus (HIV) protease gene from HIV type 1 (HIV-1)-positive (clade B), protease inhibitor-naïve patients and to evaluate its association with the subsequent effectiveness of a protease inhibitor-containing triple-drug regimen. The protease gene was sequenced from plasma-derived virus from 116 protease...
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