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Article

Analysis of the protease sequences of HIV-1 infected individuals after Indinavir monotherapy.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Oct 2003

Sa-Filho Dercy J, Costa Luciana J, de Oliveira Carlos F, Guimarães Ana Paula C, Accetturi Conceição A, Tanuri Amilcar, Diaz Ricardo S

Abstract excerpt

BACKGROUND: Protease inhibitors (PI) are an important HIV-1 treatment tool. The HIV-1 genetic diversity as a result of antiretroviral exposure is a potential barrier to successful antiretroviral therapy. OBJECTIVES: To describe the impact of the selective pressure of the PI Indinavir in the protease region of the pol gene of HIV-1. STUDY DESIGN: We have examined the extent of protease sequence heterogeneity in...

Topics

DNA, Viral
Genetic Variation
Genotype
HIV Infections
HIV Protease
HIV Protease Inhibitors
HIV-1
Humans
Indinavir
Phylogeny
Sequence Homology, Amino Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12957189
DOI: 10.1016/s1386-6532(03)00007-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12957189-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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