Article
Protease sequences from HIV-1 group M subtypes A-H reveal distinct amino acid mutation patterns associated with protease resistance in protease inhibitor-naive individuals worldwide. HIV Variant Working Group.
AIDS (London, England) - 28 Jul 2000
Pieniazek D, Rayfield M, Hu D J, Nkengasong J, Wiktor S Z, Downing R, Biryahwaho B, Mastro T, Tanuri A, Soriano V, Lal R, Dondero T
Abstract excerpt
BACKGROUND: Although numerous mutations that confer resistance to protease inhibitors (PRI) have been mapped for HIV-1 subtype B, little is known about such substitutions for the non-B viruses, which globally cause the most infections. OBJECTIVES: To determine the prevalence of PRI-associated mutations in PRI-naive individuals worldwide. DESIGN: Using the polymerase chain reaction, protease sequences were...
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