Article
HIV-2 protease sequences of subtypes A and B harbor multiple mutations associated with protease inhibitor resistance in HIV-1.
AIDS (London, England) - 20 Feb 2004
Pieniazek Danuta, Rayfield Mark, Hu Dale J, Nkengasong John N, Soriano Vincent, Heneine Walid, Zeh Clement, Agwale Simon M, Wambebe Charles, Odama Liliana, Wiktor Stefan Z
Abstract excerpt
BACKGROUND: HIV-1 protease inhibitors (PI) have been used for treating HIV-2-infected persons but little is known about amino acid mutations associated with PI resistance in HIV-2 and whether they are similar to those seen in HIV-1. OBJECTIVE: To determine the frequency of HIV-1 PI resistance-associated mutations in PI-naive HIV-2-infected individuals. DESIGN: Using PCR, protease genes were amplified from 76...
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