Article
Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene.
Leukemia research - 1 Jan 2007
Müller Claudia I, Miller Carl W, Hofmann Wolf-K, Gross Mitchell E, Walsh Christine S, Kawamata Norihiko, Luong Quang T, Koeffler H Phillip
Abstract excerpt
Lipid kinase PIK3CA mutations have been described in several cancers. They clustered in two 'hot spots' located in helical (exon 9) and kinase (exon 20) domains associated with increased kinase activity strongly suggesting oncogenic potential. Mutational analysis of previously unexamined tumors showed an amino acid change from threonine to alanine (T1025A) in exon 20 in one of 28 endometrial cancer samples and 6...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.