Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1*07.

doi:10.1089/thy.2006.16.447

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1*07.

Thyroid : official journal of the American Thyroid Association - 1 May 2006

Kula Dorota, Bednarczuk Tomasz, Jurecka-Lubieniecka Beata, Polanska Joanna, Hasse-Lazar Kornelia, Jarzab Michal, Steinhof-Radwanska Katarzyna, Hejduk Beata, Zebracka Jadwiga, Kurylowicz Alina, Bar-Andziak Ewa, Stechly Tomasz, Pawlaczek Agnieszka, Gubala Elzbieta, Krawczyk Aleksandra, Szpak-Ulczok Sylwia, Nauman Janusz, Jarzab Barbara

Abstract excerpt

OBJECTIVE: To study interactions between the two most widely confirmed Graves' disease (GD) loci: HLA-DRB1 and CTLA-4. HLA-DRB1*03 (risk allele) and DRB1*07 (protective allele) were analyzed in this aspect, the linked TNF G(-308)A polymorphism was also considered. DESIGN: A case-control study of 429 patients with GD compared to 308 healthy subjects. The impact of genes and their interactions were analyzed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antigens, Differentiation

Share to CTLA-4 Antigen

Share to Graves Disease

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Logistic Models

Share to Risk

Source

Open in PubMed

Identifiers

PMID: 16756466
DOI: 10.1089/thy.2006.16.447

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1*07.PMID 16756466Read ↗

Significance of HLA in the development of Graves’ orbitopathySemantic proximity Read ↗

Significance of HLA in the development of Graves' orbitopathy.Semantic proximity Read ↗

Primary role of the HLA class II DRB1*0301 allele in Graves disease.Semantic proximity Read ↗

Meta-Analysis of CTLA-4 +49 Gene Polymorphism and Susceptibility to Graves' Disease.Semantic proximity Read ↗

Differences in Gene-Gene Interactions in Graves' Disease Patients Stratified by Age of Onset.Semantic proximity Read ↗

Two HLA DRB 1 alleles confer independent genetic susceptibility to Graves disease: relevance of cross-population studies.Semantic proximity Read ↗

CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.Semantic proximity Read ↗

The HLA-DRB1 gene and Graves disease in Taiwanese children: a case-control and family-based study.Semantic proximity Read ↗

HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Graves' disease.Semantic proximity Read ↗

Association between age at diagnosis of Graves' disease and variants in genes involved in immune response.Semantic proximity Read ↗

Association Between HLA-DRB1 Alleles and Graves' Disease in Asian Populations: A Meta-Analysis.Semantic proximity Read ↗

Association of the HLA-DRB1*0301 and HLA-DQA1*0501 alleles with Graves' disease in a population representing the gene contribution from several ethnic backgrounds.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.