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Article

Effects of overexpression and antisense RNA expression of Orf17, a MutT-type enzyme.

Biological & pharmaceutical bulletin - 1 Jun 2006

Hori Mika, Asanuma Taketoshi, Inanami Osamu, Kuwabara Mikinori, Harashima Hideyoshi, Kamiya Hiroyuki

Abstract excerpt

The Escherichia coli Orf17 (NtpA, NudB) protein, a MutT-type enzyme, hydrolyzes oxidized deoxyribonucleotides, including 8-hydroxy-2'-deoxyadenosine 5'-triphosphate and 8-hydroxy-2'-deoxyguanosine 5'-triphosphate, in vitro. To examine its in vivo role(s) in bacteria, plasmid DNAs containing the orf17 gene in the sense and antisense orientations were introduced. When the Orf17 protein was overexpressed in mutT...

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Identifiers

PMID: 16754998
DOI: 10.1248/bpb.29.1087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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