Article
Mutational specificity of the dnaE173 mutator associated with a defect in the catalytic subunit of DNA polymerase III of Escherichia coli.
Journal of molecular biology - 20 Dec 1991
Mo J Y, Maki H, Sekiguchi M
Abstract excerpt
We developed a system to examine forward mutations that occurred in the rpsL gene of Escherichia coli placed on a multicopy plasmid. Using this system we determined the mutational specificity for a dnaE173 mutator strain in which the editing function of DNA polymerase III is impeded. The frequenc...
Topics
- Base Sequence
- Chromosome Deletion
- DNA Polymerase III
- DNA, Bacterial
- Escherichia coli
- Escherichia coli Proteins
- Frameshift Mutation
- Genes, Bacterial
- Macromolecular Substances
- Models, Genetic
- Molecular Sequence Data
- Multigene Family
- Mutagenesis, Site-Directed
- Mutation
- Nucleic Acid Conformation
- Plasmids
- Ribosomal Protein S9
- Templates, Genetic