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Article

Cutting edge: impaired transitional B cell production and selection in the nonobese diabetic mouse.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2006

Quinn William J, Noorchashm Negin, Crowley Jenni E, Reed Amy J, Noorchashm Hooman, Naji Ali, Cancro Michael P

Abstract excerpt

Developing B cells undergo selection at multiple checkpoints to eliminate autoreactive clones. We analyzed B cell kinetics in the NOD mouse to establish whether these checkpoints are intact. Our results show that although bone marrow production is normal in NOD mice, transitional (TR) B cell production collapses at 3 wk of age, reflecting a lack of successful immature B cell migration to the periphery. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16751358
DOI: 10.4049/jimmunol.176.12.7159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cutting edge: impaired transitional B cell production and selection in the nonobese diabetic mouse.PMID 16751358Read ↗

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