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Article

B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2006

William Jacqueline, Euler Chad, Primarolo Nicole, Shlomchik Mark J

Abstract excerpt

Autoreactive B cells can be regulated by deletion, receptor editing, or anergy. Rheumatoid factor (RF)-expressing B lymphocytes in normal mice are not controlled by these mechanisms, but they do not secrete autoantibody and were presumed to ignore self-Ag. Surprisingly, we now find that these B cells are not quiescent, but instead are constitutively and specifically activated by self-Ag. In BALB/c mice, RF B...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16455970
DOI: 10.4049/jimmunol.176.4.2142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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