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Article

Repertoire-based selection into the marginal zone compartment during B cell development.

The Journal of experimental medicine - 1 Sept 2008

Carey John B, Moffatt-Blue Chantelle S, Watson Lisa C, Gavin Amanda L, Feeney Ann J

Abstract excerpt

Marginal zone (MZ) B cells resemble fetally derived B1 B cells in their innate-like rapid responses to bacterial pathogens, but the basis for this is unknown. We report that the MZ is enriched in "fetal-type" B cell receptors lacking N regions (N(-)). Mixed bone marrow (BM) chimeras, made with adult terminal deoxynucleotidyl transferase (TdT)(+/+) and TdT(-/-) donor cells, demonstrate preferential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18710933
DOI: 10.1084/jem.20080559
PMCID: PMC2526199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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