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Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia.

Oncogene - 19 May 2005

Suraweera Nirosha, Meijne Emmy, Moody John, Carvajal-Carmona Luis G, Yoshida Kazuko, Pollard Patrick, Fitzgibbon Jude, Riches Andrew, van Laar Theo, Huiskamp Rene, Rowan Andrew, Tomlinson Ian P M, Silver Andrew

Abstract excerpt

Murine radiation-induced acute myeloid leukaemia (AML) is characterized by loss of one copy of chromosome 2. Previously, we positioned the critical haematopoietic-specific transcription factor PU.1 within a minimally deleted region. We now report a high frequency (>65%) of missense mutation at codon 235 in the DNA-binding Ets domain of PU.1 in murine AML. Earlier studies, outside the context of malignancy,...

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Identifiers

PMID: 15750630
DOI: 10.1038/sj.onc.1208422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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