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Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease

15 Apr 2002

Abstract excerpt

Immunoglobulin transcription is impaired in Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin disease (cHD). We recently demonstrated that defective immunoglobulin promoter transcription correlates with the down-regulation of the B-cell transcription factors Oct2 and BOB.1/OBF.1. These results prompted us to investigate whether immunoglobulin enhancer activity is also impaired in HRS cells and whether...

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PMID: 11929801
DOI: 10.1182/blood.v99.8.3060

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Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin diseasePMID 11929801Read ↗

Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcriptionSemantic proximity Read ↗

The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease.Semantic proximity Read ↗

Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells.Semantic proximity Read ↗

The early transcription factor GATA-2 is expressed in classical Hodgkin's lymphoma.Semantic proximity Read ↗

Chromatin structure and 3D architecture define differential functions of <i>PU.1</i> cis regulatory elements in human blood cell lineagesSemantic proximity Read ↗

Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphomaSemantic proximity Read ↗

Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.Semantic proximity Read ↗

Hodgkin and reed-sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription.Semantic proximity Read ↗

Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia.Semantic proximity Read ↗

Surprising new roles for PU.1 in the adaptive immune response.Semantic proximity Read ↗

Frequent Expression of the B-Cell–Specific Activator Protein in Reed-Sternberg Cells of Classical Hodgkin’s Disease Provides Further Evidence for Its B-Cell OriginSemantic proximity Read ↗

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.Semantic proximity Read ↗

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