Article
Leukemogenesis in heterozygous PU.1 knockout mice.
Radiation research - 1 Sept 2014
Genik Paula C, Vyazunova Irina, Steffen Leta S, Bacher Jeffery W, Bielefeldt-Ohmann Helle, McKercher Scott, Ullrich Robert L, Fallgren Christina M, Weil Michael M, Ray F Andrew
Abstract excerpt
Most murine radiation-induced acute myeloid leukemias involve biallelic inactivation of the PU.1 gene, with one allele being lost through a radiation-induced chromosomal deletion and the other allele affected by a recurrent point mutation in codon 235 that is likely to be spontaneous. The short latencies of acute myeloid leukemias occurring in nonirradiated mice engineered with PU.1 conditional knockout or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.