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Article

Artemin crystal structure reveals insights into heparan sulfate binding.

Biochemistry - 6 Jun 2006

Silvian Laura, Jin Ping, Carmillo Paul, Boriack-Sjodin P Ann, Pelletier Carolyn, Rushe Mia, Gong BangJian, Sah Dinah, Pepinsky Blake, Rossomando Anthony

Abstract excerpt

Artemin (ART) promotes the growth of developing peripheral neurons by signaling through a multicomponent receptor complex comprised of a transmembrane tyrosine kinase receptor (cRET) and a specific glycosylphosphatidylinositol-linked co-receptor (GFRalpha3). Glial cell line-derived neurotrophic factor (GDNF) signals through a similar ternary complex but requires heparan sulfate proteoglycans (HSPGs) for full...

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Identifiers

PMID: 16734417
DOI: 10.1021/bi060035x

Genes

GDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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