Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005

Sacher Michael, Di Bacco Alessandra, Lunin Vladimir V, Ye Zheng, Wagner John, Gill Grace, Cygler Miroslaw

Abstract excerpt

The cellular repressor of E1A-stimulated genes (CREG) is a secreted glycoprotein that inhibits proliferation and enhances differentiation of human embryonal carcinoma cells. CREG binds to the cation-independent mannose 6-phosphate (M6P)/insulin-like growth factor II (IGF2) receptor (IGF2R) (M6P/IGF2R), and this receptor has been shown to be required for CREG-induced growth suppression. To better understand CREG...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to Glycoproteins

Share to Protein Structure, Quaternary

Share to Receptor, IGF Type 2

Share to Repressor Proteins

Share to Structural Homology, Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 16344469
DOI: 10.1073/pnas.0505071102
PMCID: PMC1317909

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation.PMID 16344469Read ↗

Glycosylation-independent binding to extracellular domains 11-13 of mannose-6-phosphate/insulin-like growth factor-2 receptor mediates the effects of soluble CREG on the phenotypic modulation of vascular smooth muscle cells.Semantic proximity Read ↗

Cloning and characterization of a GC-box binding protein, G10BP-1, responsible for repression of the rat fibronectin gene.Semantic proximity Read ↗

Artemin crystal structure reveals insights into heparan sulfate binding.Semantic proximity Read ↗

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.Semantic proximity Read ↗

Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization.Semantic proximity Read ↗

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer.Semantic proximity Read ↗

Crystal structure of the N-acetylmannosamine kinase domain of GNE.Semantic proximity Read ↗

CDO: An Oncogene-, Serum-, and Anchorage-regulated Member of the Ig/Fibronectin Type III Repeat FamilySemantic proximity Read ↗

The complementary deoxyribonucleic acid sequence, tissue distribution, and cellular localization of the rat granulin precursor.Semantic proximity Read ↗

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.Semantic proximity Read ↗

Similarities in Function and Gene Structure of Cytohesin-4 and Cytohesin-1, Guanine Nucleotide-exchange Proteins for ADP-ribosylation FactorsSemantic proximity Read ↗

Characterization of the receptor binding determinants of granulocyte colony stimulating factorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.