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Article

Genetic epistasis between heparan sulfate and FGF-Ras signaling controls lens development.

Developmental biology - 1 Jul 2011

Qu Xiuxia, Hertzler Kristina, Pan Yi, Grobe Kay, Robinson Michael L, Zhang Xin

Abstract excerpt

Vertebrate lens development depends on a complex network of signaling molecules to coordinate cell proliferation, migration and differentiation. In this study, we have investigated the role of heparan sulfate in lens specific signaling by generating a conditional ablation of heparan sulfate modification genes, Ndst1 and Ndst2. In this mutant, N-sulfation of heparan sulfate was disrupted after the lens induction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21536023
DOI: 10.1016/j.ydbio.2011.04.007
PMCID: PMC3104109

Genes

FGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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