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Article

Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.

Development (Cambridge, England) - 1 Dec 2006

Pan Yi, Woodbury Andrea, Esko Jeffrey D, Grobe Kay, Zhang Xin

Abstract excerpt

Multiple signaling molecules, including bone morphogenic proteins (BMP) and fibroblast growth factors (FGF), play important roles in early lens development. However, how these morphogens are regulated is still largely unknown. Heparan sulfate participates in both morphogen transport and morphogen-receptor interaction. In this study, we demonstrate that inactivation of the heparan sulfate biosynthetic gene Ndst1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17107998
DOI: 10.1242/dev.02679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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