Article

Sulfation of glycosaminoglycans depends on catalytic activity of a lithium-inhibited phosphatase

2021-06-24

Abstract excerpt

Golgi-resident bisphosphate nucleotidase 2 (BPNT2) is a member of a family of magnesium-dependent/lithium-inhibited phosphatases that share a three-dimensional structural motif that directly coordinates metal binding to effect phosphate hydrolysis. BPNT2 is responsible for the breakdown of 3’-phosphoadenosine-5’-phosphate (PAP), a by-product of glycosaminoglycan (GAG) sulfation. Disruption of BPNT2 in mice leads t...

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Identifiers and source

Literature Corpus work: eb26629d-6071-5c6c-93ae-20d34478ae45
DOI: 10.1101/2021.06.24.449779

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