Article
Prohibitin mutations are uncommon in prostate cancer families linked to chromosome 17q.
Prostate cancer and prostatic diseases - 1 Jan 2006
White K A, Lange E M, Ray A M, Wojno K J, Cooney K A
Abstract excerpt
BACKGROUND: Linkage studies have provided evidence for a prostate cancer susceptibility locus on chromosome 17q. The mitochondrial protein prohibitin (PHB) is a plausible candidate gene based on its chromosomal location (17q21) and known function. METHODS: All coding regions and intron/exon junctions of the PHB gene were sequenced in 32 men from families participating in the University of Michigan Prostate Cancer...
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