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Article

Absence of truncating BRIP1 mutations in chromosome 17q-linked hereditary prostate cancer families.

British journal of cancer - 15 Dec 2009

Ray A M, Zuhlke K A, Johnson G R, Levin A M, Douglas J A, Lange E M, Cooney K A

Abstract excerpt

BACKGROUND: In a genome-wide scan (GWS) of 175 multiplex prostate cancer (PCa) families from the University of Michigan Prostate Cancer Genetics Project (PCGP), linkage was observed to markers on chromosome 17q21-24, a region that includes two breast cancer susceptibility genes, BRCA1 and BRIP1. BRIP1 is a Fanconi anaemia gene (FANCJ) that interacts with the BRCT domain of BRCA1 and has a role in DNA damage...

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Share to Chromosomes, Human, Pair 17
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fanconi Anemia Complementation Group Proteins

Share to Genetic Linkage

Share to Polymorphism, Single Nucleotide

Share to Prostatic Neoplasms

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Source

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Identifiers

PMID: 19935797
DOI: 10.1038/sj.bjc.6605433
PMCID: PMC2795448

Genes

BRIP1
BRCA1

Provenance

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