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Article

Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer.

The Prostate - 1 Jun 2014

Zuhlke Kimberly A, Johnson Anna M, Tomlins Scott A, Palanisamy Nallasivam, Carpten John D, Lange Ethan M, Isaacs William B, Cooney Kathleen A

Abstract excerpt

BACKGROUND: Family history of prostate cancer is a well-recognized risk factor. Previous linkage studies have reported a putative prostate cancer susceptibility locus at chromosome 17q21-22. SPOP (Speckle-type POZ protein) maps to the 17q21-22 candidate linkage region and is one of the most frequently mutated genes in sporadic prostate cancers. METHODS: We performed targeted next generation sequencing to analyze...

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Share to Chromosomes, Human, Pair 17
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Family Health

Share to Germ-Line Mutation

Share to High-Throughput Nucleotide Sequencing

Share to Mutation, Missense

Share to Prostatic Neoplasms

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Source

Open in PubMed Open full text

Identifiers

PMID: 24796539
DOI: 10.1002/pros.22818
PMCID: PMC4230298

Genes

SPOP
ERG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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