Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of PINX1 in hereditary prostate cancer.

The Prostate - 1 Sept 2004

Hawkins Gregory A, Chang Bao-Li, Zheng S Lilly, Isaacs Sarah D, Wiley Kathleen E, Bleecker Eugene R, Walsh Patrick C, Meyers Deborah A, Xu Jianfeng, Isaacs William B

Abstract excerpt

BACKGROUND: Telomerase activity is increased in most tumors. PinX1 has recently been identified as a critical component in regulating telomerase activity. The PinX1 gene is located within chromosomal region 8p22-23, a region associated with LOH and potentially linked to increased prostate cancer risk. METHODS: PINX1 was re-sequenced in 159 hereditary prostate cancer (HPC) probands. Four non-synonymous coding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Chromosomes, Human, Pair 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Loss of Heterozygosity

Share to Polymerase Chain Reaction

Share to Prostatic Neoplasms

Share to Risk Factors

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 15264240
DOI: 10.1002/pros.20075

Genes

PINX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of PINX1 in hereditary prostate cancer.PMID 15264240Read ↗

Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families.Semantic proximity Read ↗

Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk.Semantic proximity Read ↗

Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients.Semantic proximity Read ↗

Germline missense variants in the BTNL2 gene are associated with prostate cancer susceptibility.Semantic proximity Read ↗

Absence of truncating BRIP1 mutations in chromosome 17q-linked hereditary prostate cancer families.Semantic proximity Read ↗

A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region.Semantic proximity Read ↗

Mutational analysis of SPANX genes in families with X-linked prostate cancer.Semantic proximity Read ↗

ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer.Semantic proximity Read ↗

Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer.Semantic proximity Read ↗

Role of the Nijmegen breakage syndrome 1 gene in familial and sporadic prostate cancer.Semantic proximity Read ↗

A genetic epidemiological study of hereditary prostate cancer (HPC) in Finland: frequent HPCX linkage in families with late-onset disease.Semantic proximity Read ↗

Analysis of HPC1, HPCX, and PCaP in Icelandic hereditary prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.