Article
The human prohibitin (PHB) gene family and its somatic mutations in human tumors.
Genomics - 1 Sept 1993
Sato T, Sakamoto T, Takita K, Saito H, Okui K, Nakamura Y
Abstract excerpt
Five cosmid clones, isolated by procedures to screen genomic libraries for homologous variants of the human prohibitin gene (PHB), were analyzed to determine their genomic structures. Four of these (PHBP1-4) were found to be processed pseudogenes, each located on a different chromosome from their...
Topics
- Base Sequence
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 6
- Cloning, Molecular
- Cosmids
- DNA, Complementary
- Female
- Genes, Tumor Suppressor
- Humans
- In Situ Hybridization, Fluorescence
- Liver Neoplasms
- Lung Neoplasms
- Molecular Sequence Data
- Multigene Family
- Mutation
- Neoplasms
- Ovarian Neoplasms