Article
Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
Diabetes - 1 Jun 2006
Groves Christopher J, Zeggini Eleftheria, Walker Mark, Hitman Graham A, Levy Jonathan C, O'Rahilly Stephen, Hattersley Andrew T, McCarthy Mark I, Wiltshire Steven
Abstract excerpt
Obesity is a major health problem, and many family-based studies have suggested that it has a strong genetic basis. We performed a genome-wide quantitative trait linkage scan for loci influencing BMI in 573 pedigrees from the U.K. We identified genome-wide significant linkage (logarithm of odds = 3.74, between D10S208 and D10S196, genome-wide P=0.0186) on chromosome 10p. The size of our study population and the...
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