Article
A major predisposition locus for severe obesity, at 4p15-p14.
American journal of human genetics - 1 Jun 2002
Stone Steven, Abkevich Victor, Hunt Steven C, Gutin Alexander, Russell Deanna L, Neff Chris D, Riley Robyn, Frech Georges C, Hensel Charles H, Jammulapati Srikanth, Potter Jennifer, Sexton David, Tran Thanh, Gibbs Drew, Iliev Diana, Gress Richard, Bloomquist Brian, Amatruda John, Rae Peter M M, Adams Ted D, Skolnick Mark H, Shattuck Donna
Abstract excerpt
Although the predisposition to morbid obesity is heritable, the identities of the disease-causing genes are largely unknown. Therefore, we have conducted a genomewide search with 628 markers, using multigenerational Utah pedigrees to identify genes involved in predisposition to obesity. In the genomewide search, we identified a highly significant linkage to high body-mass index in female patients, at D4S2632,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.