Article
A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes.
Diabetes - 1 Sept 2002
Johnson Gillian C L, Payne Felicity, Nutland Sarah, Stevens Helen, Tuomilehto-Wolf Eva, Tuomilehto Jaakko, Todd John A
Abstract excerpt
GAD2 maps to chromosome 10p11.23 and encodes the 65-kDa isoform of GAD65, a major autoantigen in type 1 diabetes. The genetic variation that influences expression of preproinsulin mRNA, encoding another major autoantigen in type 1 diabetes, has already been shown to be genetically associated with disease. Previous reports that have assessed the association of GAD2 with type 1 diabetes have not used a dense map of...
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