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Article

GAD2 on chromosome 10p12 is a candidate gene for human obesity.

PLoS biology - 1 Dec 2003

Boutin Philippe, Dina Christian, Vasseur Francis, Dubois Séverine, Corset Laetitia, Séron Karin, Bekris Lynn, Cabellon Janice, Neve Bernadette, Vasseur-Delannoy Valérie, Chikri Mohamed, Charles M Aline, Clement Karine, Lernmark Ake, Froguel Philippe

Abstract excerpt

The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11-12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of gamma-aminobutyric acid (GABA), which interacts with neuropeptide Y in the paraventricular nucleus to contribute to stimulate food intake. A case-control study (575...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14691540
DOI: 10.1371/journal.pbio.0000068
PMCID: PMC270019

Genes

GAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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