Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Linkage disequilibrium and modification of risk for Huntington disease.

American journal of human genetics - 1 Mar 1991

Adam S, Theilmann J, Buetow K, Hedrick A, Collins C, Weber B, Huggins M, Hayden M

Abstract excerpt

The major limitation in performing predictive testing for Huntington disease (HD) is the unavailability of DNA from crucial family members. In our program approximately 20% (36/183) of persons have been excluded from predictive testing because of this reason. The major aim of this study was to examine whether data derived from linkage disequilibrium could modify risk analysis for persons at risk for HD. As a...

Topics

Adult
Alleles
Deoxyribonucleases, Type II Site-Specific
Female
Gene Frequency
Genetic Linkage
Humans
Huntington Disease
Male
Middle Aged
Mutation
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Risk Factors

United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 1671809
PMCID: PMC1682983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1671809-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Linkage disequilibrium and modification of risk for Huntington disease.PMID 1671809Read ↗

Nonrandom association between Huntington disease and two loci separated by about 3 Mb on 4p16.3.Semantic proximity Read ↗

Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population.Semantic proximity Read ↗

Complex patterns of linkage disequilibrium in the Huntington disease region.Semantic proximity Read ↗

Huntington disease in Finland: a molecular and genealogical study.Semantic proximity Read ↗

Non-random association between DNA markers and Huntington disease locus in the Italian population.Semantic proximity Read ↗

A linkage study with DNA markers (D4S95, D4S115, and D4S111) in Japanese Huntington disease families.Semantic proximity Read ↗

Genetic linkage between Huntington disease and the D4S10 locus in South African families: further evidence against non-allelic heterogeneity.Semantic proximity Read ↗

Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population.Semantic proximity Read ↗

New DNA markers in the Huntington's disease gene candidate region.Semantic proximity Read ↗

A recombination event that redefines the Huntington disease region.Semantic proximity Read ↗

ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease.Semantic proximity Read ↗

The Huntington's disease candidate region exhibits many different haplotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.