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Article

ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease.

Journal of molecular medicine (Berlin, Germany) - 1 Apr 2008

Arning Larissa, Monté Didier, Hansen Wiebke, Wieczorek Stefan, Jagiello Peter, Akkad Denis A, Andrich Jürgen, Kraus Peter H, Saft Carsten, Epplen Jörg T

Abstract excerpt

Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disease associated with abnormal expansions of a stretch of perfect CAG repeats in the HD gene. The number of repeat units is predictive for the age at onset (AO) of neurological symptoms. Part of the remaining variation in AO is attributed to modifier genes. In this study, genes involved in apoptosis were investigated as candidates...

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Identifiers

PMID: 18327563
DOI: 10.1007/s00109-007-0299-6

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PEX7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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