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Article

Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics.

The Journal of cell biology - 22 May 2006

Nayal Anjana, Webb Donna J, Brown Claire M, Schaefer Erik M, Vicente-Manzanares Miguel, Horwitz Alan Rick

Abstract excerpt

Continuous adhesion formation and disassembly (adhesion turnover) in the protrusions of migrating cells is regulated by unclear mechanisms. We show that p21-activated kinase (PAK)-induced phosphorylation of serine 273 in paxillin is a critical regulator of this turnover. Paxillin-S273 phosphorylation dramatically increases migration, protrusion, and adhesion turnover by increasing paxillin-GIT1 binding and...

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Identifiers

PMID: 16717130
DOI: 10.1083/jcb.200509075
PMCID: PMC2063867

Genes

GIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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