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Article

Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS.

The Journal of biological chemistry - 4 Nov 2011

Wade Ramon, Brimer Nicole, Lyons Charles, Pol Scott Vande

Abstract excerpt

Paxillin and HIC5 are closely related adapter proteins that regulate cell migration and are tyrosine-phosphorylated by focal adhesion kinase (FAK). Paxillin, HIC5, and FAK tyrosine phosphorylation increase upon cell attachment and decrease upon detachment from extracellular matrix. Unexpectedly, we found that although FAK tyrosine phosphorylation in attached cells did not require paxillin, in detached fibroblasts...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21900245
DOI: 10.1074/jbc.M111.294504
PMCID: PMC3207406

Genes

GIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS.PMID 21900245Read ↗

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