Article
Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS.
The Journal of biological chemistry - 4 Nov 2011
Wade Ramon, Brimer Nicole, Lyons Charles, Pol Scott Vande
Abstract excerpt
Paxillin and HIC5 are closely related adapter proteins that regulate cell migration and are tyrosine-phosphorylated by focal adhesion kinase (FAK). Paxillin, HIC5, and FAK tyrosine phosphorylation increase upon cell attachment and decrease upon detachment from extracellular matrix. Unexpectedly, we found that although FAK tyrosine phosphorylation in attached cells did not require paxillin, in detached fibroblasts...
Topics
- Actins
- Animals
- Cell Adhesion
- Cell Proliferation
- Cytoskeletal Proteins
- Cytoskeleton
- DNA-Binding Proteins
- Enzyme Activation
- Fibroblasts
- Focal Adhesion Protein-Tyrosine Kinases
- Humans
- Intracellular Signaling Peptides and Proteins
- LIM Domain Proteins
- Mice