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Article

GIT1 activates p21-activated kinase through a mechanism independent of p21 binding.

Molecular and cellular biology - 1 May 2004

Loo Tsui-Han, Ng Yuen-Wai, Lim Louis, Manser Ed

Abstract excerpt

p21-activated kinases (PAKs) associate with a guanine nucleotide exchange factor, Pak-interacting exchange factor (PIX), which in turn binds the paxillin-associated adaptor GIT1 that targets the complex to focal adhesions. Here, a detailed structure-function analysis of GIT1 reveals how this multidomain adaptor also participates in activation of PAK. Kinase activation does not occur via Cdc42 or Rac1 GTPase...

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Topics

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Share to cdc42 GTP-Binding Protein
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Share to GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

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Source

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Identifiers

PMID: 15082779
DOI: 10.1128/MCB.24.9.3849-3859.2004
PMCID: PMC387736

Genes

GIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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GIT1 activates p21-activated kinase through a mechanism independent of p21 binding.PMID 15082779Read ↗

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