Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Processes of copy-number change in human DNA: the dynamics of {alpha}-globin gene deletion.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2006

Lam Kwan-Wood G, Jeffreys Alec J

Abstract excerpt

Ectopic recombination between locally repeated DNA sequences is of fundamental importance in the evolution of gene families, generating copy-number variation in human DNA and often leading to pathological rearrangements. Despite its importance, little is known about the dynamics and processes of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to Gene Deletion
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic variations and chromosomal abnormalities

Share to Globins

Share to Haplotypes

Share to Mutation

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 16709669
DOI: 10.1073/pnas.0602690103
PMCID: PMC1482541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16709669-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Processes of copy-number change in human DNA: the dynamics of {alpha}-globin gene deletion.PMID 16709669Read ↗

Processes of <i>de novo</i> duplication of human α-globin genesSemantic proximity Read ↗

Dynamics and processes of copy number instability in human gamma-globin genes.Semantic proximity Read ↗

Allelic recombination and de novo deletions in sperm in the human beta-globin gene region.Semantic proximity Read ↗

Recombination affects accumulation of damaging and disease-associated mutations in human populations.Semantic proximity Read ↗

Recombination impacts damaging and disease mutation accumulation in human populationsSemantic proximity Read ↗

How homologous recombination generates a mutable genome.Semantic proximity Read ↗

The impact of recombination on human mutation load and disease.Semantic proximity Read ↗

Allelic recombination between distinct genomic locations generates copy number diversity in human beta-defensins.Semantic proximity Read ↗

Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection.Semantic proximity Read ↗

Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFa deletion hotspots.Semantic proximity Read ↗

Dynamic nature of the proximal AZFc region of the human Y chromosome: multiple independent deletion and duplication events revealed by microsatellite analysis.Semantic proximity Read ↗

Frequency of nonallelic homologous recombination is correlated with length of homology: evidence that ectopic synapsis precedes ectopic crossing-over.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.