Article
Frequency of nonallelic homologous recombination is correlated with length of homology: evidence that ectopic synapsis precedes ectopic crossing-over.
American journal of human genetics - 7 Oct 2011
Liu Pengfei, Lacaria Melanie, Zhang Feng, Withers Marjorie, Hastings P J, Lupski James R
Abstract excerpt
Genomic disorders constitute a class of diseases that are associated with DNA rearrangements resulting from region-specific genome instability, that is, genome architecture incites genome instability. Nonallelic homologous recombination (NAHR) or crossing-over in meiosis between sequences that are not in allelic positions (i.e., paralogous sequences) can result in recurrent deletions or duplications causing...
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