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Article

Allelic recombination between distinct genomic locations generates copy number diversity in human beta-defensins.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jan 2009

Abu Bakar Suhaili, Hollox Edward J, Armour John A L

Abstract excerpt

Beta-defensins are small secreted antimicrobial and signaling peptides involved in the innate immune response of vertebrates. In humans, a cluster of at least 7 of these genes shows extensive copy number variation, with a diploid copy number commonly ranging between 2 and 7. Using a genetic mapping approach, we show that this cluster is at not 1 but 2 distinct genomic loci approximately 5 Mb apart on chromosome...

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Identifiers

PMID: 19131514
DOI: 10.1073/pnas.0809073106
PMCID: PMC2630076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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