Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamics and processes of copy number instability in human gamma-globin genes.

Proceedings of the National Academy of Sciences of the United States of America - 4 May 2010

Neumann Rita, Lawson Victoria E, Jeffreys Alec J

Abstract excerpt

Copy number variation in the human genome is prevalent but relatively little is known about the dynamics of DNA rearrangement. We therefore used the duplicated gamma-globin genes as a simple system to explore de novo copy number changes. Rearrangements that changed gene number were seen in both germline and somatic DNA, and mainly arose by unequal sister chromatid exchange between homologous sequences, with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to gamma-Globins
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Genomic Instability

Share to Mutation

Share to Recombination, Genetic

Share to Spermatozoa

Source

Open in PubMed Open full text

Identifiers

PMID: 20404158
DOI: 10.1073/pnas.1003634107
PMCID: PMC2889564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamics and processes of copy number instability in human gamma-globin genes.PMID 20404158Read ↗

Processes of copy-number change in human DNA: the dynamics of {alpha}-globin gene deletion.Semantic proximity Read ↗

Processes of <i>de novo</i> duplication of human α-globin genesSemantic proximity Read ↗

Mechanisms for recurrent and complex human genomic rearrangements.Semantic proximity Read ↗

Diversity of human copy number variation and multicopy genes.Semantic proximity Read ↗

Pathological consequences of sequence duplications in the human genome.Semantic proximity Read ↗

Gene copy-number polymorphism caused by retrotransposition in humans.Semantic proximity Read ↗

The current excitement about copy-number variation: how it relates to gene duplications and protein familiesSemantic proximity Read ↗

Dynamic copy number evolution of X- and Y-linked ampliconic genes in human populationsSemantic proximity Read ↗

Copy Number Variation Is a Fundamental Aspect of the Placental GenomeSemantic proximity Read ↗

Copy number gain at Xp22.31 includes complex duplication rearrangements and recurrent triplications.Semantic proximity Read ↗

The Human Genome Puzzle &#x2014; the Role of Copy Number Variation in Somatic MosaicismSemantic proximity Read ↗

Chimeric chromosome landscapes of human somatic cell cultures show dependence on stress and regulation of genomic repeats by CGGBP1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.