Article
Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection.
Nature genetics - 1 Nov 2003
Repping Sjoerd, Skaletsky Helen, Brown Laura, van Daalen Saskia K M, Korver Cindy M, Pyntikova Tatyana, Kuroda-Kawaguchi Tomoko, de Vries Jan W A, Oates Robert D, Silber Sherman, van der Veen Fulco, Page David C, Rozen Steve
Abstract excerpt
Many human Y-chromosomal deletions are thought to severely impair reproductive fitness, which precludes their transmission to the next generation and thus ensures their rarity in the population. Here we report a 1.6-Mb deletion that persists over generations and is sufficiently common to be consi...
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