Article
How homologous recombination generates a mutable genome.
Human genomics - 1 Sept 2005
Hurles Matthew
Abstract excerpt
Recombination and mutation have traditionally been regarded as independent evolutionary processes: the latter generates variation, which the former reshuffles. Recent studies, however, have suggested that allelic recombination influences the underlying mutation rate, as high mutation rates are inferred in regions of high recombination. Furthermore, recombination between duplicated sequences introduces structural...
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