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Article

Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFa deletion hotspots.

Genome biology - 1 Jan 2004

Hurles Matthew E, Willey David, Matthews Lucy, Hussain Syed Sufyan

Abstract excerpt

BACKGROUND: The origins of the recombination hotspots that are a common feature of both allelic and non-allelic homologous recombination in the human genome are poorly understood. We have investigated, by comparative sequencing, the evolution of two hotspots of non-allelic homologous recombination on the Y chromosome that lie within paralogous sequences known to sponsor deletions resulting in male infertility....

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Identifiers

PMID: 15287977
DOI: 10.1186/gb-2004-5-8-r55
PMCID: PMC507880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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