Article
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2000
Rowan A J, Lamlum H, Ilyas M, Wheeler J, Straub J, Papadopoulou A, Bicknell D, Bodmer W F, Tomlinson I P
Abstract excerpt
Although APC mutations occur at a high frequency in colorectal cancers, few studies have performed a comprehensive analysis by screening the whole gene for mutations and assessing allelic loss. APC seems to act as a tumor-suppressor gene in a "nonclassical" fashion: data from familial adenomatous polyposis (FAP) show that the site of the germ-line mutation determines the type of "second hit" in FAP tumors, and...
Topics
- Base Sequence
- Colorectal Neoplasms
- Cytoskeletal Proteins
- DNA Primers
- Genes, APC
- Humans
- Loss of Heterozygosity
- Mutation
- Trans-Activators
- Tumor Cells, Cultured
- beta Catenin