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Article

Extensive molecular screening for hereditary non-polyposis colorectal cancer

1 Feb 2000

Abstract excerpt

The genetic abnormalities underlying hereditary non-polyposis colorectal cancer (HNPCC) are germline mutations in one of five DNA mismatch repair genes or in the TGFbetaRII gene. The aim of our study was to evaluate the significance of simple tests performed on tumours to select appropriate candidates for germline mutational analysis. We studied three groups of patients, HNPCC kindreds fulfilling the...

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PMID: 10732761
DOI: 10.1054/bjoc.1999.1014

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