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Article

Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population.

Journal of medical genetics - 1 Sept 2002

Yip A G, Brayne C, Easton D, Rubinsztein D C

Abstract excerpt

BACKGROUND: Apolipoprotein E (APOE) polymorphisms are unequivocally associated with risk for Alzheimer's disease (AD). It is crucial to understand how this genetic factor affects dementia risk in the general population, as well as in narrowly diagnosed, selected, patient groups. METHODS: We assessed the cross sectional association between APOE genotype and dementia status in a community based sample, the MRC...

Topics

Aged
Aged, 80 and over
Alleles
Apolipoprotein E4
Apolipoproteins E
Cognition Disorders
Dementia
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Male

Prospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 12205106
DOI: 10.1136/jmg.39.9.639
PMCID: PMC1735244

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12205106-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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