Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOE and cognitive decline in preclinical Alzheimer disease and non-demented aging.

Neurology - 14 Sept 2004

Bunce D, Fratiglioni L, Small B J, Winblad B, Bäckman L

Abstract excerpt

OBJECTIVE: To investigate whether presence of the APOE epsilon4 allele is related to the pathologic progression of preclinical Alzheimer disease (AD), as reflected by change in Mini-Mental State Examination (MMSE) scores among persons in the preclinical phase of AD, and cognitively intact adults confirmed as dementia-free during the 6-year assessment period. METHOD: In a population-based sample, participants were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Cognition Disorders
Share to Mental Status Schedule

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurologic Examination

Share to Neuropsychological Tests

Share to Sampling Studies

Share to Single-Blind Method

Share to Sweden

Source

Identifiers

PMID: 15365129
DOI: 10.1212/01.wnl.0000137041.86153.42

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE and cognitive decline in preclinical Alzheimer disease and non-demented aging.PMID 15365129Read ↗

Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease.Semantic proximity Read ↗

Decline in verbal memory during preclinical Alzheimer's disease: examination of the effect of APOE genotype.Semantic proximity Read ↗

Apolipoprotein E epsilon4 allele is unrelated to cognitive or functional decline in Alzheimer's disease: retrospective and prospective analysis.Semantic proximity Read ↗

Association between apolipoprotein E epsilon4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia.Semantic proximity Read ↗

Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population.Semantic proximity Read ↗

Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia.Semantic proximity Read ↗

APOE epsilon4 does not predict mortality, cognitive decline, or dementia in the oldest old.Semantic proximity Read ↗

Preclinical memory profile in Alzheimer patients with and without allele APOE-epsilon4.Semantic proximity Read ↗

Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease.Semantic proximity Read ↗

Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset.Semantic proximity Read ↗

Apolipoprotein E variants and cognition in healthy individuals: a critical opinion.Semantic proximity Read ↗

The role of APOE-epsilon4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.