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Article

Involvement of the beta clamp in methyl-directed mismatch repair in vitro.

The Journal of biological chemistry - 20 Nov 2009

Pluciennik Anna, Burdett Vickers, Lukianova Olga, O'Donnell Mike, Modrich Paul

Abstract excerpt

We have examined function of the bacterial beta replication clamp in the different steps of methyl-directed DNA mismatch repair. The mismatch-, MutS-, and MutL-dependent activation of MutH is unaffected by the presence or orientation of loaded beta clamp on either 3' or 5' heteroduplexes. Similarly, beta is not required for 3' or 5' mismatch-provoked excision when scored in the presence of gamma complex or in the...

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Identifiers

PMID: 19783657
DOI: 10.1074/jbc.M109.054528
PMCID: PMC2781695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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