Article
Binomial mixture model-based association tests under genetic heterogeneity.
Annals of human genetics - 1 Nov 2009
Zhou Hui, Pan Wei
Abstract excerpt
Most of the existing association tests for population-based case-control studies are based on comparing the mean genotype scores between the case and control groups, which may not be efficient under genetic heterogeneity. Given that most common diseases are genetically heterogeneous, caused by mu...
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