Significance Testing for Allelic Heterogeneity.

Abstract excerpt

It is useful to detect allelic heterogeneity (AH), i.e., the presence of multiple causal SNPs in a locus, which, for example, may guide the development of new methods for fine mapping and determine how to interpret an appearing epistasis. In contrast to Mendelian traits, the existence and extent of AH for complex traits had been largely unknown until Hormozdiari et al. proposed a Bayesian method, called causal...

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