A comparative study of sibship tests of linkage and/or association.

doi:10.1086/302104

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Article

A comparative study of sibship tests of linkage and/or association.

American journal of human genetics - 1 Nov 1998

Monks S A, Kaplan N L, Weir B S

Abstract excerpt

Population-based tests of association have used data from either case-control studies or studies based on trios (affected child and parents). Case-control studies are more prone to false-positive results caused by inappropriate controls, which can occur if, for example, there is population admixt...

Topics

Alleles
Case-Control Studies
False Positive Reactions
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Models, Genetic
Models, Statistical
Monte Carlo Method
Nuclear Family
Parents
Research Design

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