Article
Family-based samples can play an important role in genetic association studies.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2008
Lange Ethan M, Sun Jielin, Lange Leslie A, Zheng S Lilly, Duggan David, Carpten John D, Gronberg Henrik, Isaacs William B, Xu Jianfeng, Chang Bao-Li
Abstract excerpt
Over the past 2 decades, DNA samples from thousands of families have been collected and genotyped for linkage studies of common complex diseases, such as type 2 diabetes, asthma, and prostate cancer. Unfortunately, little success has been achieved in identifying genetic susceptibility risk factors through these considerable efforts. However, significant success in identifying common disease risk-associated...
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